dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye
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چکیده
منابع مشابه
dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye
Optic cups are a structural feature of diverse eyes, from simple pit eyes to camera eyes of vertebrates and cephalopods. We used the planarian prototypic eye as a model to study the genetic control of optic cup formation and regeneration. We identified two genes encoding transcription factors, sp6-9 and dlx, that were expressed in the eye specifically in the optic cup and not the photoreceptor ...
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PURPOSE The optic cup is created through invagination of the optic vesicle. The morphogenetic rearrangement creates a double-layered cup, with a hinge (the Optic Cup Lip) where the epithelium bends back upon itself. Shortly after the optic cup forms, it is thought to be sub-divided into separate lineages: i) pigmented epithelium in the outer layer; ii) presumptive iris and ciliary body at the m...
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The aim of this paper is to compare the glaucoma diagnostic reliability of two optic disc parameters: the relative cup area size determined by the Heidelberg retina tomography and the relative pallor area size determined by the proposed algorithm of the optic disc image analysis. Both parameters were measured for 240 normal healthy eyes and 240 glaucomatous eyes. The diagnostic reliability of s...
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Observations have been made of the horizontal extent of cupping of the optic nerve head in both normal and glaucomatous eyes in an attempt to determine the factors which influence cup size in the normal eye (Armaly, I967; Armaly and Sayegh, I969; Armaly, 1969a, b; Tomlinson and Phillips, I969; Jonsas, I972) and to establish differential diagnostic criteria for glaucomatous excavation (Armaly, I...
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Glaucoma is an eye disease that leads to vision loss. The symptoms of the glaucoma occurs when disease is quite advance. Glaucoma is called ‘silent thief of sight’ so, that early detection of glaucoma is very essential. In existing approach three methods are used to detect glaucoma namely Assessment of raised intraocular pressure (IOP).Assessment of abnormal visual field. Assessment of damaged ...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2011
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1002226